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The interferon‐gamma ( IFN ‐γ) +874T allele reduces the risk of hepatitis B infection in an A sian population
Author(s) -
Sun X.R.,
Wu J.,
Tang K.F.
Publication year - 2014
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12140
Subject(s) - odds ratio , genotype , allele , medicine , confidence interval , hepatitis b virus , gastroenterology , subgroup analysis , immunology , population , interferon , hepatitis b , biology , virus , gene , genetics , environmental health
Summary Increasing evidence suggests that polymorphism of the interferon‐gamma ( IFN ‐γ) gene in the first intron at position +874 may be associated with chronic hepatitis B virus ( HBV ) infection and/or HBV clearance. However, the results of relevant studies have been inconsistent. To derive a more precise estimation of the association, we performed a meta‐analysis. In total, 10 independent studies including 1661 chronic HBV ‐infected patients and 1142 controls were included in this meta‐analysis. In studies following Hardy–Weinberg equilibrium ( HWE ), a significantly decreased risk of chronic HBV infection was associated with the IFN ‐γ + 874 TT genotype in the overall population ( TT vs AA : odds ratio ( OR ) = 0.714, 95% confidence interval ( CI ) = 0.526–0.969, P = 0.031) when compared with a spontaneously recovered population. Subgroup analysis by ethnicity revealed a similar association in Asian individuals ( TT vs AA : OR = 0.706, 95% CI = 0.518–0.962, P = 0.028). Moreover, when compared with a healthy control group, the 874T allele was associated with a significant lower risk of chronic HBV infection in the overall populations ( TA vs AA : OR = 0.439, 95% CI = 0.193–0.997, P = 0.049; TT + TA vs AA : OR = 0.475, 95% CI = 0.271–0.832, P = 0.009) and in Asian individuals ( TA vs AA : OR = 0.862, 95% CI = 0.744–0.999, P = 0.048). In conclusion, the IFN ‐γ + 874 TT genotype and 874T allele reduce the risk of chronic HBV infection in Asian individuals.