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IL 28 RA polymorphism (rs10903035) is associated with insulin resistance in HIV / HCV ‐coinfected patients
Author(s) -
JiménezSousa M. A.,
Berenguer J.,
FernándezRodríguez A.,
Micheloud D.,
GuzmánFulgencio M.,
Miralles P.,
PinedaTenor D.,
García–Álvarez M.,
López J. C.,
AldámizEchevarria T.,
Carrero A.,
Resino S.
Publication year - 2014
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12130
Subject(s) - genotype , insulin resistance , interleukin 28b , hepatitis c virus , medicine , odds ratio , immunology , homeostatic model assessment , hepatitis c , gastroenterology , biology , virus , insulin , gene , genetics , ribavirin
Summary Hepatitis C virus ( HCV ) infection is associated with insulin resistance ( IR ), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of interleukin 28B ( IL28B) and interleukin 28 receptor alpha ( IL28RA ) polymorphisms with IR among human immunodeficiency virus (HIV)/HCV‐coinfected patients. We carried out a cross‐sectional study on 203 patients. IL28B (rs8099917) and IL28RA ( rs10903035) polymorphisms were genotyped by GoldenGate ® assay. IR was defined as homeostatic model assessment ( HOMA ) values ≥3.00. Univariate and multivariate generalized linear models (GLM) were used to compare HOMA values and the percentage of patients with IR according to IL28B and IL28RA genotypes. In total, 32% ( n = 65/203) of the patients had IR. IL28B rs8099917 TT was not significantly associated with HOMA values and IR . In contrast, rs10903035 AA was significantly associated with high HOMA values taking into account all patients ( P = 0.024), as well as the subgroups of patients with significant fibrosis ( P = 0.047) and infected with HCV genotype 3 ( P = 0.024). Additionally, rs10903035 AA was significantly associated with IR ( HOMA ≥3.00) in all patients (adjusted odds ratio ( aOR ) = 2.02; P = 0.034), in patients with significant fibrosis ( aOR = 2.86; P = 0.039) and HCV genotype 3 patients ( aOR = 4.89; P = 0.031). In conclusions, IL28RA polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of IR , but this association was different depending on hepatic fibrosis and HCV genotype.