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Anti‐ HBV effect of individual traditional C hinese herbal medicine in vitro and in vivo : an analytic review
Author(s) -
Chen Y.,
Zhu J.
Publication year - 2013
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12112
Subject(s) - scutellaria baicalensis , traditional medicine , in vivo , hbsag , hbeag , scutellaria , in vitro , pharmacology , hepatitis b virus , hepatitis b , traditional chinese medicine , medicine , chemistry , biology , virology , virus , biochemistry , microbiology and biotechnology , alternative medicine , pathology
Summary Traditional Chinese herbal medicine ( TCHM ) has been widely used in the treatment of chronic hepatitis B ( CHB ) in C hina. The systematic analysis of clinical research of TCHM against CHB revealed its potential but not confirmed its therapeutic effect. To understand the detailed antiviral effect of TCHM against HBV infection, we systematically analysed the anti‐ HBV effect of individual C hinese herbs on the basis of the research on individual TCHM in vitro and in vivo , which were published from 1995 to 2012. Among 171 herbal components isolated from 76 C hinese herbs, we found 13 compounds and 9 extracts isolated from 18 Chinese herbs showing strong inhibitory effect on HBV DNA , HB e A g or HB s A g release with low cytotoxicity in H ep G 2.2.15 cells, and agents from 12 C hinese herbs showing the highest inhibition rates of plasma DHBV DNA of more than 50% in DHBV ‐infected ducks. In addition, the two compounds chrysophanol 8‐ O ‐beta‐ D ‐glucoside isolated from R heum palmatum and wogonin isolated from S cutellaria baicalensis were found to display strong anti‐ HBV activity. Interestingly, compounds isolated from 5 of these effective anti‐ HBV C hinese herbs were found to show strong antibacterial or antifungal activity also. This review summarizes and analyses the studies on the anti‐ HBV effect of individual TCHM in cell and animal models, providing potential perspective in the understanding of TCHM in the treatment of hepatitis B and the development of new anti‐ HBV drugs from TCHM .