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Role of IL 28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection
Author(s) -
Seto W.K.,
Tsang O. T.Y.,
Liu K.,
Chan J. M.C.,
Wong D. K.H.,
Fung J.,
Lai C.L.,
Yuen M.F.
Publication year - 2013
Publication title -
journal of viral hepatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 100
eISSN - 1365-2893
pISSN - 1352-0504
DOI - 10.1111/jvh.12047
Subject(s) - itpa , ribavirin , genotype , interleukin 28b , pegylated interferon , hepatitis c virus , medicine , single nucleotide polymorphism , gastroenterology , immunology , virology , biology , virus , genetics , gene
Summary IL 28B and inosine triphosphatase ( ITPA ) polymorphisms are able to predict treatment response and degree of ribavirin‐related anaemia, respectively, in the treatment of chronic hepatitis C virus ( HCV ) infection. However, their roles in the treatment of chronic HCV genotype 6 remain undetermined. Sixty patients who were infected with HCV genotype 6 were commenced on 48 weeks of combination pegylated interferon and ribavirin therapy. Response to therapy, profiles of haemoglobin changes and platelet counts during therapy and their associations with IL 28B rs8099917 and ITPA rs1127354 polymorphisms were analysed. The overall sustained virologic response ( SVR ) rate was 91.7%. 18 patients (30.0%) required a reduction in ribavirin dosage. The distribution of IL 28B rs8099917 TT / TG genotypes and ITPA rs1127354 CC / CA genotypes were in Hardy–Weinberg equilibrium. IL 28B rs8099917 TT genotype, when compared to TG genotype, was significantly associated with an increased SVR rate (96.2% and 62.5%, respectively) and was the only clinical parameter that predicted SVR ( P = 0.014). The same significant association was observed when analysing allelic frequencies (T vs G, P = 0.001). ITPA rs1127354 CA genotype, when compared to CC genotype, was associated with lesser degree of anaemia throughout therapy ( P < 0.05 for all time points). ITPA polymorphisms showed no association with changes in platelet count throughout therapy ( P > 0.05 for all time points) and was not associated with SVR ( P = 0.640). In chronic HCV genotype 6 infection, IL 28B polymorphisms were associated with response to therapy. ITPA polymorphisms influenced the degree of anaemia but not thrombocytopenia during therapy.