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Remote history of VTE is associated with severe COVID‐19 in middle and older age: UK Biobank cohort study
Author(s) -
Anderson Jana J.,
Ho Frederick K.,
Niedzwiedz Claire L.,
Katikireddi Srinivasa Vittal,
CelisMorales Carlos,
Iliodromiti Stamatina,
Welsh Paul,
Pellicori Pierpaolo,
Demou Evangelia,
Hastie Claire E.,
Lyall Donald M.,
Gray Stuart R.,
Forbes John F.,
Gill Jason M. R.,
Mackay Daniel F.,
Berry Colin,
Cleland John G. F.,
Sattar Naveed,
Pell Jill P.
Publication year - 2021
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.15452
Subject(s) - medicine , poisson regression , covid-19 , confounding , cohort , cohort study , biobank , retrospective cohort study , comorbidity , medical history , population , disease , bioinformatics , environmental health , infectious disease (medical specialty) , biology
Background Venous thromboembolism (VTE) is a common, life‐threatening complication of COVID‐19 infection. COVID‐19 risk‐prediction models include a history of VTE. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID‐19. Objectives To investigate possible association between VTE and COVID‐19 severity, independent of other risk factors. Methods Cohort study of UK Biobank participants recruited between 2006 and 2010. Baseline data, including history of VTE, were linked to COVID‐19 test results, COVID‐19‐related hospital admissions, and COVID‐19 deaths. The risk of COVID‐19 hospitalization or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for sociodemographic, lifestyle, and comorbid covariates. Results After adjustment for sociodemographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with nonfatal community (RR 1.61, 95% CI 1.02–2.54, p = .039), nonfatal hospitalized (RR 1.52, 95% CI 1.06–2.17, p = .024) and severe (hospitalized or fatal) (RR 1.40, 95% CI 1.04–1.89, p = .025) COVID‐19. Associations with remote history of VTE were stronger among men (severe COVID‐19: RR 1.68, 95% CI 1.14–2.42, p = .009) than for women (severe COVID‐19: RR 1.07, 95% CI 0.66–1.74, p = .786). Conclusion Our findings support inclusion of remote history of VTE in COVID‐19 risk‐prediction scores, and consideration of sex‐specific risk scores.