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Recommendations for clinical laboratory testing for protein S deficiency: Communication from the SSC committee plasma coagulation inhibitors of the ISTH
Author(s) -
Marlar Richard A.,
Gausman Ja.,
Tsuda Hiroko,
RollinsRaval Marian A.,
Brinkman Herm Jan M.
Publication year - 2021
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.15109
Subject(s) - medicine , coagulation testing , intensive care medicine , coagulation , disease , thrombosis , bioinformatics , immunology , pathology , biology
Hereditary deficiencies of protein S (PS) increase the risk of venous thrombosis; however, assessing the plasma levels of PS can be difficult because of its complex physiological interactions in plasma, sample‐related preanalytical variables, and numerous acquired disease processes. Reliable laboratory assays are essential for accurate evaluation of PS when diagnosing a congenital deficiency based on the plasma phenotype alone. This report presents the current evidence‐based recommendations for clinical PS assays as well as when to test for PS abnormalities.