Premium
Macrothrombosis and stroke in patients with mild Covid‐19 infection
Author(s) -
Fara Michael G.,
Stein Laura K.,
Skliut Maryna,
Morgello Susan,
Fifi Johanna T.,
Dhamoon Mandip S.
Publication year - 2020
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.14938
Subject(s) - medicine , stroke (engine) , coagulopathy , covid-19 , thrombosis , disease , pandemic , thrombotic microangiopathy , thrombus , coronavirus , intensive care medicine , infectious disease (medical specialty) , mechanical engineering , engineering
Coronavirus disease 2019 (COVID‐19) is a pandemic disease currently affecting millions of people worldwide. Its neurological implications are poorly understood, and further study is urgently required. A hypercoagulable state has been reported in patients with severe COVID‐19, but nothing is known about coagulopathy in patients with milder disease. We describe cases of patients in New York City presenting with stroke secondary to large vessel thrombosis without occlusion, incidentally found to have COVID‐19 with only mild respiratory symptoms. This is in contrast to the venous thrombosis and microangiopathy that has been reported in patients with severe COVID‐19. Our cases suggest that even in the absence of severe disease, patients with COVID‐19 may be at increased risk of thrombus formation leading to stroke, perhaps resulting from viral involvement of the endothelium. Further systematic study is needed because this may have implications for primary and secondary stroke prevention in patients with COVID‐19.