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The prevention and management of asparaginase‐related venous thromboembolism in adults: Guidance from the SSC on Hemostasis and Malignancy of the ISTH
Author(s) -
Zwicker Jeffrey I.,
Wang TzuFei,
DeAngelo Daniel J.,
Lauw Mandy N.,
Connors Jean M.,
Falanga Anna,
McMasters Malgorzata,
Carrier Marc
Publication year - 2020
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.14671
Subject(s) - medicine , asparaginase , thrombosis , venous thrombosis , intensive care medicine , hemostasis , complication , malignancy , chemotherapy , warfarin , lymphoblastic leukemia , leukemia , atrial fibrillation
Venous thromboembolism is a common complication of asparaginase‐based chemotherapy regimens for the treatment of acute lymphoblastic leukemia. Thrombosis associated with asparaginase administration poses a number of specific and often clinically challenging management decisions. This review provides guidance on the prevention and treatment of thrombosis associated with asparaginase in adults including discussions on antithrombin repletion, pharmacologic thromboprophylaxis, cerebral venous thrombosis, and therapeutic anticoagulation.