Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application | Zendy

Diaz Jose A. | Zendy; Saha Prakash | Zendy; Cooley Brian | Zendy; Palmer Olivia R. | Zendy; Grover Steven P. | Zendy; Mackman Nigel | Zendy; Wakefield Thomas W. | Zendy; Henke Peter K. | Zendy; Smith Alberto | Zendy; Lal Brajesh K. | Zendy

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Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application

Author(s) -

Diaz Jose A.,

Saha Prakash,

Cooley Brian,

Palmer Olivia R.,

Grover Steven P.,

Mackman Nigel,

Wakefield Thomas W.,

Henke Peter K.,

Smith Alberto,

Lal Brajesh K.

Publication year - 2019

Publication title -

journal of thrombosis and haemostasis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.947

H-Index - 178

eISSN - 1538-7836

pISSN - 1538-7933

DOI - 10.1111/jth.14413

Subject(s) - selection (genetic algorithm) , computer science , venous thrombosis , consensus conference , deep vein , medicine , thrombosis , machine learning , surgery , library science

Summary Murine models are widely used valuable tools to study deep vein thrombosis ( VT ). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT . In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT . Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.

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