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Choosing a mouse model of venous thrombosis: a consensus assessment of utility and application
Author(s) -
Diaz Jose A.,
Saha Prakash,
Cooley Brian,
Palmer Olivia R.,
Grover Steven P.,
Mackman Nigel,
Wakefield Thomas W.,
Henke Peter K.,
Smith Alberto,
Lal Brajesh K.
Publication year - 2019
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.14413
Subject(s) - selection (genetic algorithm) , computer science , venous thrombosis , consensus conference , deep vein , medicine , thrombosis , machine learning , surgery , library science
Summary Murine models are widely used valuable tools to study deep vein thrombosis ( VT ). Leading experts in VT research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of VT . In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of VT . Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.