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The perils of inhibiting deficient factors
Author(s) -
Sayar Z.,
Speed V.,
Patel J. P.,
Patel R. K.,
Arya R.
Publication year - 2018
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.14195
Subject(s) - rivaroxaban , medicine , warfarin , atrial fibrillation , prothrombin complex concentrate , anticoagulant , edoxaban , surgery
Essentials Anticoagulation in patients with factor X deficiency is an evidence‐poor area. A patient with factor X deficiency was anticoagulated with warfarin followed by rivaroxaban. Warfarin may be a safer anticoagulant option than rivaroxaban in hereditary factor X deficiency. A baseline coagulation screen should be performed prior to commencement of anticoagulation.Summary We report a case of a previously undiagnosed factor X deficiency in an 83‐year‐old man who had no previous bleeding history despite multiple hemostatic challenges. He was anticoagulated with warfarin for atrial fibrillation without bleeding complications; however, major hemorrhage occurred soon after a switch to rivaroxaban.