Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH

Perioperative bleeding is a common complication following major surgery. Despite surgical measures to minimize bleeding, patients develop acquired hemostatic defects due to multiple factors that include hemorrhagic loss, consumption, dilution of coagulation factors and platelets, hypothermia, acidosis, and activation of fibrinolytic and inflammatory pathways. Therapeutic approaches for restoring haemostasis include allogeneic blood product administration.This article is protected by copyright. All rights reserved.