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Chronic complications of venous thromboembolism
Author(s) -
Winter M.P.,
Schernthaner G. H.,
Lang I. M.
Publication year - 2017
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.13741
Subject(s) - medicine , deep vein , pulmonary embolism , thrombus , thrombosis , post thrombotic syndrome , chronic thromboembolic pulmonary hypertension , disease , venous thromboembolism , venous thrombosis , intensive care medicine
Summary Venous thromboembolism ( VTE ) is a common disease (~700 per 100 000) that is associated with significant risk of recurrence, chronic complications, and substantial mortality, with reported death rates of up to 40% at 10 years. The development of novel anticoagulants has revolutionized the treatment of acute VTE , while strategies for prevention and treatment of chronic complications still seek for such a landmark change. Impaired thrombus resolution is the common denominator behind VTE complications, which are postthrombotic syndrome ( PTS ) and chronic thromboembolic pulmonary hypertension ( CTEPH ). PTS and CTEPH are associated with substantial morbidity and high healthcare expenses. While PTS occurs in up to 50% of patients after symptomatic deep vein thrombosis, only a small and poorly defined number of patients are diagnosed with CTEPH after pulmonary embolism. This review is a comprehensive summary of VTE ‐related chronic complications, their epidemiology, diagnosis, and treatment.