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Medical device‐induced thrombosis: what causes it and how can we prevent it?
Author(s) -
Jaffer I. H.,
Fredenburgh J. C.,
Hirsh J.,
Weitz J. I.
Publication year - 2015
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.12961
Subject(s) - thrombus , thrombosis , medicine , medical device , intensive care medicine , cardiology , biomedical engineering , surgery
Summary Blood‐contacting medical devices, such as vascular grafts, stents, heart valves, and catheters, are often used to treat cardiovascular diseases. Thrombus formation is a common cause of failure of these devices. This study (i) examines the interface between devices and blood, (ii) reviews the pathogenesis of clotting on blood‐contacting medical devices, (iii) describes contemporary methods to prevent thrombosis on blood‐contacting medical devices, (iv) explains why some anticoagulants are better than others for prevention of thrombosis on medical devices, and (v) identifies future directions in biomaterial research for prevention of thrombosis on blood‐contacting medical devices.