Premium
α II bβ3: structure and function
Author(s) -
Coller B. S.
Publication year - 2015
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.12915
Subject(s) - integrin , ligand (biochemistry) , biophysics , chemistry , receptor , lipid bilayer , mechanism (biology) , platelet activation , function (biology) , computational biology , microbiology and biotechnology , platelet , biochemistry , biology , immunology , philosophy , membrane , epistemology
Summary During the past decade, advanced techniques in structural biology have provided atomic level information on the platelet integrin α II bβ3 activation mechanism that results in it adopting a high‐affinity ligand‐binding conformation(s). This review focuses on advances in imaging intact α II bβ3 in a lipid bilayer in the absence of detergent and new structural insights into the changes in the ligand‐binding pocket with receptor activation and ligand binding. It concludes with descriptions of novel therapeutic α II bβ3 antagonists being developed based on an advanced knowledge of the receptor's structure.