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Platelet surface expression of stromal cell–derived factor‐1 receptors CXCR 4 and CXCR 7 is associated with clinical outcomes in patients with coronary artery disease
Author(s) -
Rath D.,
Chatterjee M.,
Borst O.,
Müller K.,
Langer H.,
Mack A. F.,
Schwab M.,
Winter S.,
Gawaz M.,
Geisler T.
Publication year - 2015
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.12870
Subject(s) - medicine , stromal cell derived factor 1 , percutaneous coronary intervention , hazard ratio , myocardial infarction , cardiology , coronary artery disease , proportional hazards model , conventional pci , cxcr4 , confidence interval , receptor , chemokine
Summary Background Surface expression of stromal cell–derived factor‐1 ( SDF ‐1, CXCL 12) on platelets is enhanced during ischemic events and plays an important role in peripheral homing of stem cells and myocardial repair mechanisms. SDF ‐1 effects are mediated through CXCR 4 and CXCR 7. Both CXCR 4 and CXCR 7 are surface expressed on human platelets and to a higher degree in patients with coronary artery disease ( CAD ) compared with healthy controls. In this study, we investigated the prognostic role of platelet CXCR 4‐ and CXCR 7 surface expression in patients with symptomatic CAD . Methods and results In a cohort study, platelet surface expression of CXCR 4 and CXCR 7 was measured by using flow cytometry in 284 patients with symptomatic CAD at the time of percutaneous coronary intervention ( PCI ). The primary combined end point was defined as all‐cause death and/or myocardial infarction ( MI ) during 12‐month follow‐up. Secondary end points were defined as the single events of all‐cause death and MI . We found significant differences of CXCR 4 values in patients who developed a combined end point compared with event‐free patients (mean MFIAUTHOR : Please define MFI at first use. 3.17 vs. 3.44, 95% confidence interval [ CI ] 0.09–0.45) and in patients who subsequently died (mean MFI 3.10 vs. 3.42, 95% CI 0.09–0.56). In multivariate Cox regression analysis, lower platelet CXCR 4 levels were independently and significantly associated with all‐cause mortality (hazard ratio 0.24, 95% CI 0.07–0.87) and the primary combined end point of all‐cause death and/or MI (hazard ratio 0.30, 95% CI 0.13–0.72). Conclusion These findings highlight a potential prognostic value of platelet expression CXCR 4 on clinical outcomes in patients with CAD .