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Family history of venous thromboembolism ( VTE ) and risk of recurrent hospitalization for VTE : a nationwide family study in S weden
Author(s) -
Zöller B.,
Ohlsson H.,
Sundquist J.,
Sundquist K.
Publication year - 2014
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.12499
Subject(s) - medicine , family history , pulmonary embolism , venous thromboembolism , hazard ratio , deep vein , sibling , confidence interval , pediatrics , risk factor , medical history , thrombosis , venous thrombosis , psychology , developmental psychology
Summary Background Data concerning the importance of a family history of venous thromboembolism ( VTE ) for the risk of recurrent VTE are sparse. The aim of this nationwide study was to determine whether a family history of VTE is a risk factor for recurrent hospitalization for unprovoked VTE (deep vein thrombosis of the lower extremities or pulmonary embolism). Methods We linked M ultigeneration Register data on individuals aged 0–77 years to the S wedish nationwide H ospital D ischarge R egister data for the period 1987–2009 to compare the risk of hospitalization for unprovoked recurrent VTE among individuals with and without a parental or sibling history of VTE . We calculated hazard ratios ( HR s) to determine the familial HR for recurrent hospitalization for VTE . Results and Conclusions The risk of recurrent VTE hospitalization was 1.20 (95% confidence interval [ CI ] 1.10–1.32) for individuals with affected parents, and 1.30 (95% CI 1.14–1.49) for those with affected siblings. The risk of recurrent VTE hospitalization in individuals with two affected parents was 1.92 (95% CI 1.44–2.58). There was an interaction between age at diagnosis of VTE and a family history of VTE , with a family history having a stronger effect on VTE risk in younger patients. We conclude that a family history of VTE is a modest risk factor for recurrent VTE hospitalization in Sweden.