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Activated platelets correlate with mobilization of naïve CD 34 + cells and generation of CD 34 + / KDR + cells in the circulation. A meta‐regression analysis
Author(s) -
Boer H. C.,
OeverenRietdijk A. M.,
Rotmans J. I.,
Dekkers O. M.,
Rabelink T. J.,
Zonneveld A. J.
Publication year - 2013
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.12315
Subject(s) - cd34 , bone marrow , progenitor cell , platelet , kinase insert domain receptor , haematopoiesis , stem cell , biology , cancer research , immunology , medicine , microbiology and biotechnology , vascular endothelial growth factor , vascular endothelial growth factor a , vegf receptors
Summary Background Bone marrow‐derived circulating CD 34 + progenitor cells participate in remodeling and repair of the vasculature. Coexpression of the kinase‐insert domain‐containing receptor ( KDR ) has been proposed to identify the regenerative capacity. Recently, we provided evidence that the major fraction of circulating CD 34 + / KDR + cells is not mobilized from bone marrow, but is generated at sites of vascular injury through interaction with platelets. Objectives To determine the relationship between platelet activation, the recruitment of naïve CD 34 + cells and the generation of CD 34 + / KDR + progenitor cells in a broad range of (patho)physiologic conditions, a detailed meta‐regression analysis was conducted. Methods/Results Twenty‐eight conditions were found in which the numbers of CD 34 + and/or CD 34 + / KDR + cells and the levels of soluble P ‐selectin, as a marker for in vivo platelet activation, were documented. To combine heterogeneous data from 214 selected articles, results were standardized to a uniform scale by calculating standardized mean differences ( SMD s) obtained from patient and control cohorts. Subsequently, a random‐effects meta‐regression analysis was performed on pooled SMD s. Conclusions Our systemic survey supports a model in which activated platelets are a determinant for mobilization of CD 34 + cells from the bone marrow and the generation of CD 34 + / KDR + cells in the circulation.