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Micro RNA s in platelet production and activation
Author(s) -
Edelstein L. C.,
McKenzie S. E.,
Shaw C.,
Holinstat M. A.,
Kunapuli S. P.,
Bray P. F.
Publication year - 2013
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.12214
Subject(s) - megakaryocytopoiesis , microrna , biology , haematopoiesis , transcriptome , microbiology and biotechnology , platelet , erythropoiesis , biogenesis , megakaryocyte , stem cell , computational biology , platelet disorder , genetics , gene expression , immunology , gene , medicine , anemia
Summary Recent work by the E ncyclopedia of DNA Elements project showed that non‐protein‐coding RNA s account for an unexpectedly large proportion of the human genome. Among these non‐coding RNA s are micro RNA s (mi RNA s), which are small RNA molecules that modulate protein expression by degrading m RNA or repressing m RNA translation. Mi RNA s have been shown to play important roles in hematopoiesis including embryonic stem cell differentiation, erythropoiesis, granulocytopoiesis/monocytopoiesis, lymphopoiesis, and megakaryocytopoiesis. Additionally, disordered mi RNA biogenesis and quantitative or qualitative alterations in mi RNA s and their targets are associated with hematological pathologies. Platelets contain machinery to process pre‐mi RNA s into mature mi RNA s, and specific platelet mi RNA levels have been found to correlate with platelet reactivity. This review summarizes the current state of knowledge of mi RNA s in megakaryocytes and platelets, and the exciting possibilities for future megakaryocyte–platelet transcriptome research.