Premium
Tissue factor non‐coagulant signaling – molecular mechanisms and biological consequences with a focus on cell migration and apoptosis
Author(s) -
Åberg M.,
Siegbahn A.
Publication year - 2013
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/jth.12156
Subject(s) - microbiology and biotechnology , signal transduction , tissue factor , receptor tyrosine kinase , protein kinase b , cell signaling , biology , juxtacrine signalling , transactivation , cancer research , receptor , chemistry , autocrine signalling , coagulation , transcription factor , biochemistry , medicine , psychiatry , gene
Summary Tissue factor ( TF ), a transmembrane glycoprotein, is the main initiator of the blood coagulation cascade. TF is also recognized as a true signaling receptor. There is accumulating evidence that the downstream signaling effects of the TF complexes are transduced by several mechanisms, including: activation of protease‐activated receptor ( PAR )‐1 and PAR ‐2, and the PAR ‐dependent pathways, via the TF cytoplasmic domain and by transactivation of receptor tyrosine kinases. Triggering of signaling cascades such as the mitogen‐activated protein kinase and phosphoinositide 3‐kinase/ AKT pathways couples TF to a multitude of functions within the cell, such as proliferation, cell migration, and survival. Thus, TF has a Janus face; on the one hand, it has vital life‐maintaining functions, and on the other it has harmful effects, exemplified by inflammation, the acute coronary syndromes, and cancer. TF mediates a broad spectrum of signaling mechanisms. Learning more about these different mechanisms/pathways will lead to new treatment strategies, which can ultimately be personalized.