Premium
The urge to move: From restless legs syndrome to impulse control disorders in Parkinson’s disease
Author(s) -
Marques Ana,
Figorilli Michela,
Lambert Céline,
Pereira Bruno,
Vidal Tiphaine,
Montplaisir Jacques,
Durif Franck,
Livia Fantini Maria
Publication year - 2021
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/jsr.13127
Subject(s) - restless legs syndrome , parkinson's disease , medicine , ropinirole , disease , population , impulse control , impulse control disorder , dopamine agonist , physical therapy , physical medicine and rehabilitation , pediatrics , levodopa , dopamine , psychiatry , neurology , dopaminergic , environmental health , pathological
Impulse control disorders (ICDs) in Parkinson's disease (PD) are defined as a failure to resist an “urge” to behave in a way that may be debilitating for oneself or others. The suggested immobilization test (SIT) has been developed to assess the “urge” to move and support the diagnosis of restless legs syndrome (RLS) in the general population and in PD. A clinical association between RLS and ICDs has been shown in PD and in the general population. We hypothesized that there could be a semiological overlap between RLS and ICDs, and conducted SIT in PD patients with and without ICDs. Fifty PD patients with ( n = 17) and without ( n = 33) current ICDs were included. SIT, videopolysomnography, demographical treatment, and motor, psycho‐behavioural and sleep characteristics, including RLS, were recorded. PD patients with ICDs reported increased subjective discomfort during SIT (SD‐SIT) compared to those without ICDs ( p = .024). Multivariable analysis confirmed ICDs as an independent factor associated with increased SD‐SIT in PD, regardless of the presence of RLS, PD severity and dopamine agonist treatment dose. The discomfort measured by SIT might not only reflect the “urge” to move in RLS but also the ICDs in PD, suggesting that ICDs and RLS in PD could share a common phenomenology.