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Association between central sleep apnea and left ventricular structure: the Multi‐Ethnic Study of Atherosclerosis
Author(s) -
Javaheri Sogol,
Sharma Ravi K.,
Bluemke David A.,
Redline Susan
Publication year - 2017
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/jsr.12501
Subject(s) - central sleep apnea , ethnic group , sleep apnea , cardiology , association (psychology) , medicine , polysomnography , apnea , psychology , political science , law , psychotherapist
Summary We assessed whether the presence of central sleep apnea is associated with adverse left ventricular structural changes. We analysed 1412 participants from the Multi‐Ethnic Study of Atherosclerosis who underwent both overnight polysomnography and cardiac magnetic resonance imaging. Subjects had been recruited 10 years earlier when free of cardiovascular disease. Our main exposure is the presence of central sleep apnea as defined by central apnea–hypopnea index = 5 or the presence of Cheyne–Stokes breathing. Outcome variables were left ventricular mass/height, left ventricular ejection fraction, and left ventricular mass/volume ratio. Multivariate linear regression models adjusted for age, gender, race, waist circumference, tobacco use, hypertension, and the obstructive apnea–hypopnea index were fit for the outcomes. Of the 1412 participants, 27 (2%) individuals had central sleep apnea. After adjusting for covariates, the presence of central sleep apnea was significantly associated with elevated left ventricular mass/volume ratio ( β = 0.11 ± 0.04 g mL −1 , P = 0.0071), an adverse cardiac finding signifying concentric remodelling.