Premium
The interaction of sleep and amyloid deposition on cognitive performance
Author(s) -
Molano Jennifer R. V.,
Roe Catherine M.,
Ju YoEl S.
Publication year - 2017
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/jsr.12474
Subject(s) - actigraphy , effects of sleep deprivation on cognitive performance , psychology , dementia , audiology , sleep (system call) , cognition , amyloid (mycology) , clinical psychology , medicine , psychiatry , disease , insomnia , pathology , computer science , operating system
Summary Sleep difficulties are emerging as a risk factor for dementia. This study examined the effect of sleep and amyloid deposition on cognitive performance in cognitively normal adults. Sleep efficiency was determined by actigraphy. Cerebrospinal fluid A β 42 levels <500 pg mL −1 , indicating amyloid deposition, was present in 23 participants. Psychometric tests included the Free and Cued Selective Reminding Test, Trail Making Test A and B, Animal Fluency, Letter Number Sequencing, and the Mini Mental State Examination. The interaction term of sleep efficiency and amyloid deposition status was a significant predictor of memory performance as measured by total Selective Reminding Test scores. While Trail Making Test B performance was worse in those with amyloid deposition, sleep measures did not have an additive effect. In this study, amyloid deposition was associated with worse cognitive performance, and poor sleep efficiency specifically modified the effect of amyloid deposition on memory performance.