Possible influence of  AMPD 1 on cholinergic neurotransmission and sleep | Zendy

Buyse Bertien | Zendy; Van Damme Philip | Zendy; Belge Catharina | Zendy; Testelmans Dries | Zendy

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Possible influence of AMPD 1 on cholinergic neurotransmission and sleep

Author(s) -

Buyse Bertien,

Van Damme Philip,

Belge Catharina,

Testelmans Dries

Publication year - 2016

Publication title -

journal of sleep research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.297

H-Index - 117

eISSN - 1365-2869

pISSN - 0962-1105

DOI - 10.1111/jsr.12341

Subject(s) - sleep (system call) , polysomnography , slow wave sleep , multiple sleep latency test , cholinergic , non rapid eye movement sleep , medicine , sleep onset , wakefulness , neurotransmission , endocrinology , psychology , neuroscience , electroencephalography , sleep disorder , insomnia , excessive daytime sleepiness , apnea , psychiatry , receptor , computer science , operating system

Summary It is known that adenosine excess due to monophosphate deaminase deficiency (AMPD1) can be linked to muscle problems. Recently, Perumal et al ., 2014 reported a first case of possible impact of AMPD1 on sleep, REM sleep and cholinergic neurotransmission. We report a second patient with similar sleep complaints: long sleep duration with residual daytime sleepiness and a need to sleep after exercise. On polysomnography we observed a long sleep duration, with high sleep efficiency and a SOREMP; on MSLT a shortened sleep latency and 4 SOREMPS were observed. Frequency power spectral heart rate analysis during slow wave sleep, REM sleep and wakefulness revealed an increased parasympathetic tone. In conclusion, AMPD1 could have a profound influence on cholinergic neurotransmission and sleep; further studies are mandatory.

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