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Possible influence of AMPD 1 on cholinergic neurotransmission and sleep
Author(s) -
Buyse Bertien,
Van Damme Philip,
Belge Catharina,
Testelmans Dries
Publication year - 2016
Publication title -
journal of sleep research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.297
H-Index - 117
eISSN - 1365-2869
pISSN - 0962-1105
DOI - 10.1111/jsr.12341
Subject(s) - sleep (system call) , polysomnography , slow wave sleep , multiple sleep latency test , cholinergic , non rapid eye movement sleep , medicine , sleep onset , wakefulness , neurotransmission , endocrinology , psychology , neuroscience , electroencephalography , sleep disorder , insomnia , excessive daytime sleepiness , apnea , psychiatry , receptor , computer science , operating system
Summary It is known that adenosine excess due to monophosphate deaminase deficiency (AMPD1) can be linked to muscle problems. Recently, Perumal et al ., 2014 reported a first case of possible impact of AMPD1 on sleep, REM sleep and cholinergic neurotransmission. We report a second patient with similar sleep complaints: long sleep duration with residual daytime sleepiness and a need to sleep after exercise. On polysomnography we observed a long sleep duration, with high sleep efficiency and a SOREMP; on MSLT a shortened sleep latency and 4 SOREMPS were observed. Frequency power spectral heart rate analysis during slow wave sleep, REM sleep and wakefulness revealed an increased parasympathetic tone. In conclusion, AMPD1 could have a profound influence on cholinergic neurotransmission and sleep; further studies are mandatory.