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Evaluation of the effect of vincristine on platelet count in dogs with lymphoma
Author(s) -
Campbell O.,
MacDonald V. S.,
Dickinson R. M.,
Gag J.
Publication year - 2019
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/jsap.13080
Subject(s) - vincristine , medicine , platelet , lymphoma , canine lymphoma , incidence (geometry) , clinical significance , gastroenterology , chemotherapy , cyclophosphamide , physics , optics
Objectives To determine the effect of vincristine administration on the platelet count, platelet morphology and incidence of thrombocytopenia in dogs diagnosed with lymphoma. Material and Methods Medical records of 59 dogs with lymphoma receiving vincristine sulphate were reviewed retrospectively. Results Following vincristine administration the platelet count was higher and the number of thrombocytopenic patients was lower. No difference was found in the number of dogs with enlarged and elliptical platelets following vincristine treatment. Clinical Significance Vincristine administration increases platelet counts in dogs with lymphoma. It is not contra‐indicated to administer vincristine to dogs with lymphoma that are thrombocytopenic.