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Comparison of initial treatment with and without corticosteroids for suspected acute pancreatitis in dogs
Author(s) -
Okanishi H.,
Nagata T.,
Nakane S.,
Watari T.
Publication year - 2019
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/jsap.12994
Subject(s) - prednisolone , medicine , acute pancreatitis , pancreatitis , c reactive protein , cure rate , gastroenterology , mortality rate , clinical practice , anesthesia , surgery , inflammation , physical therapy
Objectives To compare initial treatment with and without corticosteroids for acute pancreatitis in dogs and investigate the therapeutic efficacy and prognosis. Materials and Methods Sixty‐five dogs were included in this non‐blinded, non‐randomised clinical study. Dogs with acute pancreatitis received treatment either with dose of 1 mg/kg/day prednisolone (n=45) or without prednisolone (n=20). Response to treatment was based on changes in the C‐reactive protein concentration, improvement in clinical signs, duration of hospitalisation, mortality and recurrence rate. Results From the third day of hospitalisation, C‐reactive protein concentration was significantly lower in the prednisolone group than that in the non‐prednisolone group. The number of days required to reach a C‐reactive protein concentration of <2 mg/dL and clinical score of ≤2 was significantly lower in the prednisolone group. The mortality rate 1 month after discharge was significantly lower in the prednisolone group (11.3% versus 46.1%). Clinical Significance In dogs with acute pancreatitis, initial treatment with prednisolone resulted in earlier reductions in C‐reactive protein concentration and earlier improvement of clinical signs.