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Treatment of canine sinonasal aspergillosis with clotrimazole infusion in patients with cribriform plate lysis
Author(s) -
Stanton J. A.,
Miller M. L.,
Johnson P.,
Davig D. L.,
Barr S. C.
Publication year - 2018
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/jsap.12835
Subject(s) - medicine , cribriform , clotrimazole , cribriform plate , aspergillosis , pathology , surgery , dermatology , antifungal , immunohistochemistry , immunology
Objective To describe the treatment of sinonasal aspergillosis with topical 1% clotrimazole solution in dogs with cribriform plate lysis. Materials and Methods This retrospective study includes data retrieval from medical records of dogs with sinonasal aspergillosis and cribriform plate lysis that underwent topical treatment with 1% clotrimazole solution. Results Five dogs with sinonasal aspergillosis, cribriform plate lysis diagnosed on CT scans, and normal neurologic examinations were treated with a single (n=3) or multiple (n=2) infusions of clotrimazole solution. No dogs developed clinical neurologic disease after therapy. Clinical Significance In this study, a topical clotrimazole solution was not associated with adverse neurologic effects in neurologically normal dogs with sinonasal aspergillosis and cribriform plate lysis.