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Analysis of serum corticosteroid‐induced alkaline phosphatase isoenzyme in dogs with hepatobiliary diseases
Author(s) -
Kojima K.,
Ohno K.,
Kanemoto H.,
GotoKoshino Y.,
Fukushima K.,
Tsujimoto H.
Publication year - 2017
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/jsap.12623
Subject(s) - alkaline phosphatase , medicine , corticosteroid , endocrinology , glucocorticoid , hepatobiliary disease , isozyme , enzyme , biology , biochemistry
O bjective To reveal the relationship between canine corticosteroid‐induced alkaline phosphatase isoenzyme activity and hepatobiliary diseases. M aterials and M ethods Retrospective analysis of the relationship between serum corticosteroid‐induced alkaline phosphatase activity and diagnosis, serum cortisol concentration and alanine transferase activity in dogs with hepatobiliary diseases. Dogs with a history of glucocorticoid administration were excluded. R esults Seventy‐two dogs with hepatobiliary diseases were analysed. The serum corticosteroid‐induced alkaline phosphatase concentration was increased in dogs with hepatobiliary diseases. There was no correlation between serum cortisol concentration and serum corticosteroid‐induced alkaline phosphatase percentage or activity. C linical S ignificance Dogs with hepatobiliary disease can exhibit high serum alkaline phosphatase activity even if the dogs have not been administrated glucocorticoids and the serum cortisol concentration is normal.