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Serum C‐reactive protein and S100A12 concentrations in dogs with hepatic disease
Author(s) -
Craig S. M.,
Fry J. K.,
Rodrigues Hoffmann A.,
Manino P.,
Heilmann R. M.,
Suchodolski J. S.,
Steiner J. M.,
Hottinger H. A.,
Hunter S. L.,
Lidbury J. A.
Publication year - 2016
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/jsap.12504
Subject(s) - c reactive protein , medicine , inflammation , acute phase protein , gastroenterology , liver biopsy , biopsy , pathology
OBJECTIVES To describe serum C‐reactive protein and S100A12 concentrations in dogs with hepatic disease and to determine whether there is a relationship between the concentration of either and the severity of hepatic necroinflammation. METHODS Serum C‐reactive protein and S100A12 concentrations were measured in 46 dogs undergoing hepatic biopsy. Dogs were divided into three groups: congenital portosystemic shunts, chronic hepatitis and hepatic neoplasia. The histological severity of hepatic necroinflammation was scored. RESULTS C‐reactive protein and S100A12 concentrations were greater than the upper limit of the reference intervals in 39 and 26% of dogs, respectively. There was no association of disease group with C‐reactive protein (P=0·1733) or S100A12 (P=0·1513) concentrations. There was a positive correlation between serum C‐reactive protein concentration and hepatic necroinflammatory activity (r s =0·428, P=0·006). CLINICAL SIGNIFICANCE Increased serum C‐reactive protein and S100A12 concentrations were observed in a subpopulation of dogs with various types of hepatic diseases, suggesting acute‐phase inflammation and activation of phagocytic cells, respectively. Dogs with higher hepatic necroinflammatory activity scores tended to have higher serum C‐reactive protein concentrations. Further studies are needed to confirm this finding in a larger group of dogs.