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Evaluation of urinary biomarkers for azotaemic chronic kidney disease in cats
Author(s) -
Williams T. L.,
Archer J.
Publication year - 2016
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/jsap.12439
Subject(s) - creatinine , medicine , urine , urine specific gravity , cystatin c , kidney disease , urology , renal function , endocrinology , cats , kidney , albumin
OBJECTIVES Evaluation of urine albumin:creatinine ratio, urine cystatin C:creatinine ratio, urine protein:creatinine ratio and urine specific gravity as screening tests for azotaemic chronic kidney disease in cats. METHODS A group of cats over eight years old were defined as either (i) healthy non‐azotaemic (n=40) if they had serum creatinine concentration <153 µmol/L and no history of apparent disease or (2) having azotaemic chronic kidney disease (n=12) if they had serum creatinine concentration >153 µmol/L with urine specific gravity <1·035. Urine albumin:creatinine ratio, urine cystatin C:creatinine ratio, urine protein:creatinine ratio and urine specific gravity were compared between the two groups. RESULTS Urine cystatin C:creatinine ratio was significantly lower in cats with azotaemic chronic kidney disease than that in healthy cats [3·7 (1·4, 4·3)×10 −6 versus 13·9 (6·3, 24·7)×10 −6 ; P=0·011]. Urine specific gravity was also significantly lower in the azotaemic chronic kidney disease group than that in the healthy group [1·022 (1·017, 1·028) versus 1·043 (1·034, >1·050); P<0·001]. Urine albumin:creatinine ratio and urine protein:creatinine ratio were not significantly different between the groups (P=0·075 and P=0·965, respectively). CLINICAL SIGNIFICANCE Urine cystatin C:creatinine ratio and urine specific gravity were significantly lower in cats with azotaemic chronic kidney disease than that in healthy cats; however, neither biomarker was an adequate sole screening test for azotaemic chronic kidney disease.