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The effect of prophylactic topical carbonic anhydrase inhibitors in canine primary closed‐angle glaucoma
Author(s) -
Stavinohova R.,
Newton J. R.,
Busse C.
Publication year - 2015
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/jsap.12393
Subject(s) - dorzolamide , medicine , intraocular pressure , glaucoma , timolol , ophthalmology , carbonic anhydrase inhibitor , anesthesia , carbonic anhydrase , biochemistry , chemistry , enzyme
OBJECTIVES To determine the effect of 1% brinzolamide, 2% dorzolamide hydrochloride or combination 2% dorzolamide hydrochloride/0 · 5% timolol to delay the elevation of the intraocular pressure in second eyes of dogs with primary closed‐angle glaucoma. METHODS Analysis of retrospectively collated data from 40 dogs with primary closed‐angle glaucoma, where the non‐affected eye was treated prophylactically with brinzolamide (n = 10), dorzolamide (n = 18) or combination dorzolamide/timolol therapy (n = 12). RESULTS The 40 treated dogs (median age of 76 · 2 months) comprised 25 females/15 males, 19 entire/21 neutered. Twenty dogs developed glaucoma in the contralateral eye (median time of 9 · 2 months). No statistically significant difference was identified during treatment failure between the treatment groups (P = 0 · 66). The second eye remained normotensive in 20 dogs; four dogs until the conclusion of the study (median: 27 · 0 months), three dogs until death (median: 15 · 4 months), seven dogs until lost to follow‐up (median: 11 · 6 months). Out of these 20 dogs, treatment was discontinued because of lack of owner compliance in two dogs and following a local drug reaction in four dogs (median: 8 · 9 months). CLINICAL SIGNIFICANCE There was no evidence that the tested drugs delayed elevation of intraocular pressure in contralateral eyes of dogs with primary closed‐angle glaucoma.