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Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial
Author(s) -
GonzálezSerrano José,
LópezPintor Rosa María,
Serrano Julia,
Torres Jesús,
Hernández Gonzalo,
Sanz Mariano
Publication year - 2021
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12886
Subject(s) - medicine , tannerella forsythia , bleeding on probing , mucositis , randomized controlled trial , dentistry , placebo , mann–whitney u test , peri implantitis , clinical trial , propolis , implant , surgery , gastroenterology , periodontitis , traditional medicine , chemotherapy , alternative medicine , honeysuckle , pathology , traditional chinese medicine
Objective To determine the efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the treatment of peri‐implant mucositis (PM). Background Propolis has anti‐inflammatory and antibacterial effect that may improve peri‐implant health. Methods A randomized, double‐blind study was performed on patients with at least one implant with PM. Participants received a professional prophylaxis and were instructed to use either test or a control gel as toothpaste three times/day for 1 month. Clinical and microbiological parameters were evaluated. PM resolution was considered in absence of bleeding on probing (BOP). Data were analysed with Mann‐Whitney U , Wilcoxon signed‐rank and chi‐square tests. Results Forty‐six patients participated (23 in each group). After treatment, 26.1% of test patients showed complete PM resolution versus 0% in control group ( p = .02). Significant reductions were observed in plaque index ( p = .03), BOP ( p = .04) and probing depths ( p = .027) in test compared with control group. The reduction in Tannerella forsythia was statistically greater in test than in control group at 1‐month follow‐up ( p = .02). Porphyromonas gingivalis was statistically reduced in test group from baseline to 1‐month follow‐up ( p = .05). Conclusion Test gel clinically improved PM and showed certain antimicrobial effect after 1 month in comparison with control group. Further long‐term clinical trials are required to confirm these results.