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Lactic acid bacteria prevent both periodontitis and atherosclerosis exacerbated by periodontitis in spontaneously hyperlipidemic mice
Author(s) -
Kobayashi Ryoki,
HashizumeTakizawa Tomomi,
KuritaOchiai Tomoko
Publication year - 2021
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12874
Subject(s) - periodontitis , porphyromonas gingivalis , lactic acid , medicine , inflammation , lesion , oral administration , lactobacillus gasseri , bacteria , endocrinology , lactobacillus , pathology , biology , genetics
Background and Objective Recent studies have shown a link between periodontal disease and cardiovascular disease. We have previously reported that oral administration of Porphyromonas gingivalis ( Pg ) accelerates atherosclerosis in apolipoprotein E‐deficient spontaneously hyperlipidemic (Apoe shl ) mice. This study evaluated the potential of lactic acid bacteria (LAB) to change the intestinal flora changes induced by periodontopathic bacteria and to prevent/slow down the development of atherosclerosis. Methods Lactobacillus gasseri O3‐2 ( Lg ) was orally intubated in Apoe shl mice for 5 weeks. Three weeks after oral intubation, the mice were orally infected with Pg for 2 weeks. Results Thirty days after the last infection with Pg , Lg +Pg‐treated mice showed a significant reduction in alveolar bone loss compared to the Pg ‐treated group. The Lg treatment restored the Pg ‐induced intestinal flora disturbance to normal. Furthermore, a significant decrease in atherosclerotic plaque lesion size and suppressed inflammatory cytokine production in the aorta were detected in the Lg + Pg‐treated group. In contrast, blood concentrations of TMAO, histidine, and carnitine were enhanced by the Lg treatment but decreased by Lg + Pg treatment. Conclusion These results suggest that oral Lg treatment is effective in preventing periodontitis and atherosclerosis.