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Biological response to peri‐implantitis treatment
Author(s) -
Bhavsar Ishita,
Miller Craig S.,
Ebersole Jeffrey L.,
Dawson Dolphus R.,
Thompson Katherine L.,
AlSabbagh Mohanad
Publication year - 2019
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12681
Subject(s) - peri implantitis , bleeding on probing , medicine , implant , peri , dentistry , antimicrobial , matrix metalloproteinase 9 , matrix metalloproteinase , periodontitis , gastroenterology , chemistry , surgery , organic chemistry
Objective To investigate biological markers of peri‐implantitis (PIP) in crevicular fluid before and after surgical and antimicrobial therapy. Material and Methods Forty‐eight participants (24 healthy implants and 24 PIP) were clinically evaluated, and peri‐implant crevicular fluid (PICF) samples were collected at baseline for both groups, and at 3‐months after surgical and antimicrobial treatment (ie, n = 21 PIP completers). Samples were analyzed for interleukin‐1β (IL‐1β), matrix metalloproteinase‐8 (MMP‐8), and macrophage inflammatory protein‐1α (MIP‐1α) using immunoassay and the results compared between groups. Results Peri‐implantitis sites at baseline demonstrated significantly higher mean periodontal probing depths, percentage bleeding on probing ( P ≤ 0.001), and mean IL‐1β concentration in PICF compared to healthy implant sites (17.9 vs 1.7 pg/μL; P = 0.02). Three months after treatment, periodontal probing depths, bleeding on probing, suppuration ( P < 0.05), and the mean concentration of MMP‐8 decreased significantly compared with baseline (12.1 vs 6.7 ng/μL, P = 0.04). MIP‐1α concentrations showed no differences between the groups. Conclusion Elevated concentrations of IL‐1β in PICF were consistent with PIP. A decrease in MMP‐8 concentration in PICF at three months after treatment is consistent with a healing biological response.