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Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis
Author(s) -
Masumoto Risa,
Kitagaki Jirouta,
Fujihara Chiharu,
Matsumoto Masahiro,
Miyauchi Shizuka,
Asano Yoshihiro,
Imai Atsuko,
Kobayashi Kaori,
Nakaya Akihiro,
Yamashita Motozo,
Yamada Satoru,
Kitamura Masahiro,
Murakami Shinya
Publication year - 2019
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12620
Subject(s) - aggressive periodontitis , chronic periodontitis , periodontitis , association (psychology) , medicine , genetic association , identification (biology) , genome wide association study , genetics , single nucleotide polymorphism , dentistry , biology , genotype , gene , psychology , botany , psychotherapist
To identify the genetic risk factors for aggressive periodontitis (AgP), it is important to understand the progression and pathogenesis of AgP. The purpose of this review was to summarize the genetic risk factors for AgP identified through a case‐control genomewide association study (GWAS) and replication study. The initial studies to identify novel AgP risk factors were potentially biased because they relied on previous studies. To overcome this kind of issue, an unbiased GWAS strategy was introduced to identify genetic risk factors for various diseases. Currently, three genes glycosyltransferase 6 domain containing 1 ( GLT6D1 ), defensin α 1 and α 3 ( DEFA1A3 ), and sialic acid‐binding Ig‐like lectin 5 ( SIGLEC5 ) that reach the threshold for genomewide significance have been identified as genetic risk factors for AgP through a case‐control GWAS.