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The periodontal stem/progenitor cell inflammatory‐regenerative cross talk: A new perspective
Author(s) -
Fawzy ElSayed Karim M.,
Elahmady Maryam,
Adawi Zeina,
Aboushadi Nour,
Elnaggar Ali,
Eid Maryam,
Hamdy Nayera,
Sanaa Dalia,
Dörfer Christof E.
Publication year - 2019
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12616
Subject(s) - progenitor cell , stem cell , microbiology and biotechnology , mesenchymal stem cell , multipotent stem cell , adult stem cell , biology , homing (biology) , progenitor , immunology , periodontal ligament stem cells , endothelial stem cell , in vitro , ecology , biochemistry , alkaline phosphatase , enzyme
Adult multipotent stem/progenitor cells, with remarkable regenerative potential, have been isolated from various components of the human periodontium. These multipotent stem/progenitor cells include the periodontal ligament stem/progenitor cells ( PDLSC s), stem cells from the apical papilla ( SCAP ), the gingival mesenchymal stem/progenitor cells (G‐ MSC s), and the alveolar bone proper stem/progenitor cells ( AB ‐ MSC s). Whereas inflammation is regarded as the reason for tissue damage, it also remains a fundamental step of any early healing process. In performing their periodontal tissue regenerative/reparative activity, periodontal stem/progenitor cells interact with their surrounding inflammatory micro‐environmental, through their expressed receptors, which could influence their fate and the outcome of any periodontal stem/progenitor cell‐mediated reparative/regenerative activity. The present review discusses the current understanding about the interaction of periodontal stem/progenitor cells with their surrounding inflammatory micro‐environment, elaborates on the inflammatory factors influencing their stemness, proliferation, migration/homing, differentiation, and immunomodulatory attributes, the possible underlying intracellular mechanisms, as well as their proposed relationship to the canonical and noncanonical Wnt pathways.