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Association of LTA gene haploblock with periodontal disease in Italian adults
Author(s) -
Zupin Luisa,
Moura Rodrigues Ronald,
Navarra Chiara Ottavia,
Bevilacqua Lorenzo,
Catamo Eulalia,
Di Lenarda Roberto,
Gasparini Paolo,
Crovella Sergio,
Robino Antonietta
Publication year - 2019
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12609
Subject(s) - periodontitis , chronic periodontitis , haplotype , immune system , immunology , major histocompatibility complex , biology , disease , locus (genetics) , medicine , gene , genetics , allele , pathology , dentistry
Background Periodontitis is a common oral disease caused by host inflammatory response towards bacteria biofilm. The chronic activation of immune response leads to destruction of teeth supporting tissue, bone loss and tooth detachment. Different factors could be involved in the development and severity of the disease; among them the host genetic background should be considered. Objectives In our study, we analysed haploblocks in a genomic region within major histocompatibility complex ( MHC ) locus aimed at disclosing a possible correlation with the risk of periodontal disease in 602 adult subjects from North‐East Italy. Results The CTTAC haploblock (formed by LTA ‐rs2857709, LTA ‐rs2844484, LTA ‐ rs2229094, LTA ‐rs2229092 and LTA ‐rs1041981 polymorphisms) correlated with protection towards periodontitis condition, after regression analysis including age and smoking status as covariates ( P ‐value = 0.015). Conclusion Our results suggest that a haplotype within LTA gene (encoding for lymphotoxin alpha) is involved in the susceptibility towards chronic periodontitis.