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Periodontal condition and levels of bacteria associated with periodontitis in individuals with bipolar affective disorders: A case‐control study
Author(s) -
Cunha Fabiano A.,
Cota Luís O. M.,
Cortelli Sheila C.,
Miranda Tais B.,
Neves Fernando S.,
Cortelli José R.,
Costa Fernando O.
Publication year - 2019
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12605
Subject(s) - treponema denticola , periodontitis , aggregatibacter actinomycetemcomitans , medicine , aggressive periodontitis , porphyromonas gingivalis , logistic regression , case control study , dentistry , odds ratio , epidemiology , bleeding on probing
Objective To evaluate the epidemiological and microbiological aspects of the potential association between bipolar affective disorder ( BAPD ) and periodontitis. Methodology The present case‐control study comprised 176 individuals with BAPD and 176 controls. All individuals underwent a complete full‐mouth periodontal examination and microbiological sampling. Data on bleeding on probing, probing depth, and clinical attachment level in all present teeth were recorded. Quantification of total bacterial load and Aggregatibacter actinomycetemcomitans, Treponema denticola , and Porphyromonas gingivalis counts were performed through qPCR . Data were analyzed using univariate analysis, Spearman correlation and multivariate logistic regression. Results The prevalence of periodontitis was 39.7% among controls and 58.5% among individuals with BAPD ( OR = 2.13; 95% CI 1.39‐3.27). A. actinomycetemcomitans and P. gingivalis counts were significantly higher in individuals with BPAD and periodontitis. The final multivariate logistic regression revealed that periodontitis was strongly associated with the total bacterial load ( OR = 1.91; 95% IC = 1.0‐1.99; P < 0.001) and the depressive phase of BPAD ( OR = 28.94; 95% IC = 4.44‐177.27; P < 0.001). Conclusion BAPD was associated with increased risk for periodontitis. Individuals with BPAD presented higher levels of A. actinomycetemcomitans and P. gingivalis , suggesting that periodontitis could be a co‐morbidity frequently found in individuals with BAPD .