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Single nucleotide polymorphisms in long noncoding RNA , ANRIL , are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease
Author(s) -
Schulz S.,
Seitter L.,
Werdan K.,
Hofmann B.,
Schaller H.G.,
Schlitt A.,
Reichert S.
Publication year - 2018
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12555
Subject(s) - single nucleotide polymorphism , periodontitis , proportional hazards model , medicine , snp , myocardial infarction , hazard ratio , coronary artery disease , genotype , oncology , cardiology , biology , genetics , gene , confidence interval
Background and Objective Biological plausibility of an association between severe periodontitis and cardiovascular disease (CVD) has been proven. Genetic characteristics play an important role in both complex inflammatory diseases. Polymorphisms (single nucleotide polymorphisms [ SNP s]) in the long noncoding RNA, antisense noncoding RNA in the INK 4 locus ( ANRIL), were shown to play a leading role in both diseases. The primary objectives of the study were to assess, among cardiovascular (CV angiographically proven ≥50% stenosis of a main coronary artery) patients, the impact of ANRIL SNP s rs133049 and rs3217992 on the severity of periodontitis and the previous history of coronary events, as well as on the occurrence of further adverse CV events. Material and Methods The prevalence of severe periodontitis was analyzed in 1002 CV patients. ANRIL SNP s rs133049 and rs3217992 were genotyped. The prognostic value of both ANRIL SNP s for combined CV endpoint (stroke/transient ischemic attack [ TIA] , myocardial infarction, death from a CV‐related event, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios ( HR s) were adjusted for established CV risk factors applying Cox regression. Results ANRIL SNP s rs133049 and rs3217992 were not associated with severe periodontitis or history of CVD in CV patients. In the Kaplan‐Meier survival curve including the log rank‐test ( P = .036) and Cox regression (hazard ratio = 1.684, P = .009) the AA genotype of rs3217992 was shown to be an independent predictor for adverse CV events after 3 years of follow‐up. Conclusion SNP s in ANRIL are not risk modulators for severe periodontitis and history of CVD in CV patients. The AA genotype of ANRIL SNP s rs3217992 possesses prognostic power for further CV events within 3 years of follow‐up.