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Brain natriuretic peptide serum levels in periodontitis
Author(s) -
Leira Y.,
Blanco J.
Publication year - 2018
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12547
Subject(s) - periodontitis , medicine , biomarker , brain natriuretic peptide , periodontal examination , inflammation , natriuretic peptide , clinical attachment loss , gastroenterology , periodontal disease , disease , heart failure , biology , biochemistry
Background and Objective N‐terminal‐pro‐brain natriuretic peptide ( NT ‐pro BNP ) is expressed during inflammation and considered to be a biomarker of cardiovascular disease ( CVD ). In the last decade, evidence has suggested that periodontitis is associated with CVD . However, little is known of the potential role of this peptide in periodontal disease. The aims of this study were to examine whether the levels of NT ‐pro BNP in serum are increased in periodontal disease and if there is a relationship to severity of periodontitis. Material and Methods A case‐control study was carried out, in which serum samples were collected from 40 patients with periodontitis and from 40 nonperiodontitis individuals. Full periodontal examination was performed in all subjects. Demographic information, and clinical and history of certain diseases were also recorded. Determinations of serum NT ‐pro BNP and high‐sensitivity C‐reactive protein concentrations were carried out in an independent laboratory. Results The levels of NT ‐pro BNP in serum were significantly higher in patients with periodontitis compared with controls (87.9 pg/mL vs 29.9 pg/ mL , P < .0001). In addition, as periodontal disease progressed, the levels of NT ‐pro BNP increased. Multivariable regression analysis showed that the periodontal inflamed surface area, a measure of periodontal inflammation and disease activity, was the only periodontal parameter significantly associated with elevated concentrations of NT ‐pro BNP in serum ( R 2 = .777, P < .0001). Conclusion In periodontitis, increased serum NT ‐pro BNP levels are observed in comparison with individuals without periodontitis. Moreover, the greater the degree of periodontal destruction, the higher the levels of NT ‐pro BNP in serum.