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Susceptibility of different mouse strains to peri‐implantitis
Author(s) -
Hiyari S.,
Naghibi A.,
Wong R.,
Sadreshkevary R.,
YiLing L.,
Tetradis S.,
Camargo P. M.,
Pirih F. Q.
Publication year - 2018
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12493
Subject(s) - peri implantitis , pathogenesis , ligature , osseointegration , implant , medicine , bone remodeling , pathology , dentistry , surgery
Background and Objective Peri‐implantitis ( PI ) is an inflammatory condition that affects the tissues surrounding dental implants. Although the pathogenesis of PI is not fully understood, evidence suggests that the etiology is multifactorial and may include a genetic component. The aim of this study was to investigate the role of genetics in the development of peri‐implantitis. Material and Methods Four‐week‐old C57 BL /6J, C3H/HeJ and A/J male mice had their left maxillary molars extracted. Implants were placed in the healed extraction sockets. Upon osseointegration, ligatures were placed around the implant head for 1 or 4 weeks to induce PI . Micro‐computed tomography scanning was used to measure volumetric bone loss. Histological analyses were also performed to evaluate collagen organization and the presence of neutrophils and osteoclasts. Results Radiographically, comparing the ligature‐treated mice, C57 BL /6J displayed the greatest amount of bone loss, followed by C3H/HeJ and A/J mice at 1 and 4 weeks. Histologically, at 1 week, C57 BL /6J mice presented with the highest numbers of neutrophils and osteoclasts. At 4 weeks, C57 BL /6J mice presented with the most active bone remodeling compared with the other two strains. Conclusion There were significant differences in the severity of peri‐implantitis among the different mouse strains, suggesting that the genetic framework can affect implant survival and success. Future work is needed to dissect the genetic contribution to the development of peri‐implantitis.