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Is obesity associated with healing after non‐surgical periodontal therapy? A local vs. systemic evaluation
Author(s) -
Duzagac E.,
Cifcibasi E.,
Erdem M. G.,
Karabey V.,
Kasali K.,
Badur S.,
Cintan S.
Publication year - 2016
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12340
Subject(s) - medicine , adiponectin , adipokine , periodontitis , triglyceride , obesity , chronic periodontitis , gastroenterology , endocrinology , tumor necrosis factor alpha , lipoprotein , interleukin 6 , inflammation , cholesterol , leptin , insulin resistance
Background We aimed to detect the role of obesity on the healing response to periodontal therapy in terms of serum lipids, C‐reactive protein ( CRP) and both serum and gingival crevicular fluid adipocytokines. Material and Methods Thirty patients with periodontitis with ( CPO ) ( n = 15) and without ( n = 15) obesity and 15 healthy controls were included. Serum high‐density lipoprotein , low‐density lipoprotein , triglyceride , CRP levels and levels of adiponectin, interleukin ( IL) ‐6, tumor necrosis factor ( TNF) ‐α and IL ‐10 were evaluated before and 3 mo after initial periodontal therapy. Clinical periodontal measurements were also recorded at baseline and 3 mo. Results Periodontal parameters improved significantly in both periodontitis groups with or without obesity ( p < 0.05) with no significant difference in terms of gain clinical attachment level ( p > 0.05) and change in numbers of sites with probing depth ≥ 4 mm. High‐density lipoprotein significantly increased in both groups ( p > 0.05). CRP decreased significantly solely in the normal weight group. IL ‐6, IL ‐10 and TNF ‐α levels in gingival crevicular fluid improved significantly based on therapy in both groups ( p < 0.05). Only TNF ‐α decreased significantly in the CPO , while adiponectin and IL ‐10 in addition to TNF ‐α improved significantly in the group of patients with periodontitis without obesity. Conclusion Patients with CPO respond to periodontal therapy as well as the non‐obese controls. This similar response is accompanied with consistent adipokine levels in gingival crevicular fluid . However, obesity affects the CRP and serum adipocytokine levels in response to therapy.