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Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment
Author(s) -
Nibali L.,
Rizzo M.,
Li Volti G.,
D'Aiuto F.,
Giglio R. V.,
Barbagallo I.,
Pelekos G.,
Donos N.
Publication year - 2015
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12283
Subject(s) - oxidative stress , periodontitis , medicine , lipid profile , lipoprotein , high density lipoprotein , cholesterol , endocrinology , blood lipids , haplotype , confounding , aggressive periodontitis , biology , biochemistry , genotype , gene
Background and Objective Associations between dyslipidaemia, oxidative stress and periodontitis have emerged in recent years. However, there is a lack of studies investigating these associations in aggressive periodontitis (AgP) cases. The aim of this study was to investigate the lipid and oxidative stress profiles in patients with AgP, and to relate them to clinical variables and interleukin ( IL )‐6 genetic variants. Material and Methods Twelve non‐smoking Caucasian patients with AgP selected based on their IL 6 haplotypes underwent periodontal non‐surgical and surgical treatment. Peripheral blood samples taken at baseline and at six different time‐points after treatment were processed to determine IL‐ 6 circulating levels, lipid profiles (cholesterol, triglycerides, high‐density lipoprotein [ HDL] and low‐density lipoprotein [ LDL] subclasses) and oxidative stress markers (glutathione and total lipid hydroperoxide levels). Results HDLs were the most prevalent lipoproteins, followed by intermediate‐density lipoprotein , very‐low‐density lipoprotein and LDL . The LDL subclasses consisted mainly of the less atherogenic large LDL . The lipid profile did not consistently change after treatment up to 3 mo after surgery. Periodontal disease severity was associated with LDL levels and size. The IL 6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders. IL ‐6 circulating levels were associated with both very‐low‐density lipoprotein and lipid hydroperoxide levels. Conclusion Based on these data, we conclude that both periodontal disease severity and IL 6 haplotypes may influence lipid profiles in AgP.