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The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis
Author(s) -
Machado W. M.,
Prestes A. P.,
Costa T. P.,
Mendes R. T.,
Olchanheski L. R.,
Sordi R.,
Otuki M. F.,
Fávero G. M.,
Vellosa J. C. R.,
Santos F. A.,
Fernandes D.
Publication year - 2014
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12145
Subject(s) - simvastatin , periodontitis , medicine , systemic inflammation , inflammation , endothelial dysfunction , ligature , dental alveolus , sodium nitroprusside , endocrinology , pharmacology , nitric oxide , dentistry
Background and Objective It has been demonstrated that periodontitis induces systemic inflammation, which may impair endothelial function leading to increased cardiovascular risk. The aim of this study was to evaluate the effect of simvastatin on systemic inflammatory markers and endothelial dysfunction induced by periodontitis. Material and Methods Wistar rats were subjected to ligature‐induced experimental periodontitis. Eight days after the procedure, the ligature and sham groups were randomly assigned to receive simvastatin or vehicle once a day until the 14th day, when the effects of acetylcholine and sodium nitroprusside on blood pressure were evaluated. Blood samples were collected and evaluated for plasma interleukin‐6 C , ‐reactive protein and lipids. The maxilla and mandible were removed for bone loss analysis. Results Simvastatin treatment reduced systemic inflammation and endothelial dysfunction induced by periodontitis. Furthermore, simvastatin improved the blood lipid profile and reduced alveolar bone loss. Conclusion Simvastatin treatment, in addition to the improvement on serum lipid profile, may reduce other predictors of cardiovascular events associated with periodontitis.