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Relationship between salivary leukotriene B 4 levels and salivary mucin or alveolar bone resorption, in subjects with periodontal health and disease
Author(s) -
Sánchez G. A.,
Miozza V. A.,
Delgado A.,
Busch L.
Publication year - 2013
Publication title -
journal of periodontal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.31
H-Index - 83
eISSN - 1600-0765
pISSN - 0022-3484
DOI - 10.1111/jre.12070
Subject(s) - mucin , saliva , periodontitis , dental alveolus , bone resorption , medicine , leukotriene b4 , immunology , pathology , inflammation , dentistry
Objective Here we determine the salivary levels of leukotriene B 4 ( LTB 4 ) and its relation with salivary mucin and alveolar bone level. Background LT B 4 is a membrane‐derived lipid mediator formed from arachidonic acid. It is among the most potent stimulants of polymorphonuclear leukocytes providing the first host defense against infections. Leukotrienes also induce bone resorption. Because LTB 4 is present in the oral cavity the aim of the present study was to explore the role of LTB 4 in patients with periodontal disease. Methods Eighty‐one subjects were clinically examined and distributed into four groups, namely, clinically healthy, mild, moderate and severe periodontitis, according to periodontal status, classified into values of clinical attachment level and probing pocket depth. Unstimulated saliva was collected for 5 min. Salivary LTB 4 was determined by an immune assay method, mucin was determined by a colorimetric method and radiographic assessment used to determine alveolar bone level. Results Patients with mild periodontitis showed a decrease in salivary LTB 4 levels while patients with severe periodontitis showed increased LTB 4 levels. A significant positive correlation was observed between salivary LTB 4 and clinical attachment level, salivary mucin concentration or alveolar bone level. Conclusion The close relation between salivary LTB 4 and mucin levels suggested that LTB 4 might be involved in the defense mechanism of the oral cavity. The correlation of LTB 4 with the alveolar bone level indicates that they are one of the mediators responsible for bone resorption.

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