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Pulmonary hypertension and right ventricular failure in broiler chickens reared at high altitude is affected by dietary source of n‐6 and n‐3 fatty acids
Author(s) -
Rostami A.,
Zamani Moghaddam A. K.,
Hassanpour H.,
Khajali F.
Publication year - 2016
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/jpn.12432
Subject(s) - broiler , effects of high altitude on humans , malondialdehyde , pulmonary hypertension , feed conversion ratio , completely randomized design , zoology , fatty acid , weight gain , polyunsaturated fatty acid , nitric oxide , biology , medicine , endocrinology , biochemistry , body weight , oxidative stress , anatomy
Summary The present study evaluated the development of pulmonary hypertension and right ventricular failure in broiler chickens reared at high altitude (2100 m) as affected by dietary intake of n‐3 and n‐6 fatty acid sources. Flax oil and soy oil were used as sources of n‐3 and n‐6 fatty acids, respectively, either with or without α ‐tocopheryl acetate. A total of 192 day‐old broiler chicks (Ross 308) were used in a completely randomized design using isoenergetic and isonitrogenous experimental diets. Results showed that dietary flax oil significantly (p < 0.05) improved feed conversion ratio during 21–42 days of age. However, body weight gain did not significantly differ among the experimental groups in entire trial. Birds received flax oil had significantly higher serum concentration of nitric oxide (NO) but they had lower serum concentration of malondialdehyde when compared with their counterparts fed with soy oil. Liver and abdominal fat weights were significantly (p < 0.05) reduced by substitution of soy oil for flax oil. The right‐to‐total ventricle weight ratio ( RV / TV ) and mortality from pulmonary arterial hypertension ( PAH ) were significantly (p < 0.05) decreased in birds that received flax oil. In conclusion, n‐3 fatty acids could significantly reduce RV : TV and PAH mortality in birds by increasing circulatory level of NO and suppressing hepatic lipogenesis.