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Influence of dietary nicotinic acid supplementation on lipid metabolism and related gene expression in two distinct broiler breeds of female chickens
Author(s) -
Jiang R. R.,
Zhao G. P.,
Zhao J. P.,
Chen J. L.,
Zheng M. Q.,
Liu R. R.,
Wen J.
Publication year - 2014
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/jpn.12138
Subject(s) - nefa , broiler , endocrinology , medicine , breed , adiponectin , zoology , apolipoprotein b , chemistry , biology , lipid metabolism , cholesterol , obesity , insulin , insulin resistance
Summary This study aimed to evaluate the influence of supplemental dietary nicotinic acid ( NA ) on lipid metabolism and hepatic expression of related genes in female chickens of two distinct broiler strains [ A rbor A cres ( AA ) and B eijing‐ Y ou ( BJY ) ]. The treatments were arranged in a 2 × 4 factorial in a completely randomized design. Day‐old females ( n = 384) were allocated to four treatments with six cages per treatment and fed diets (basal contained approximately 25 mg NA/kg) supplemented with 0, 30, 60 and 120 mg NA/kg. A sample of 72 birds from each breed was slaughtered and sampled at their different market times (8 week for AA and 16 week for BJY ). A rbor A cres broilers had thickness of subcutaneous fat plus the skin ( SFS ), and plasma concentration of low‐density lipoprotein cholesterol ( LDLC ) and lower percentage of abdominal fat ( PAF ), plasma concentrations of TG , NEFA and adiponectin than the BJY line. The hepatic transcription of apolipoprotein A ‐ I ( A po A ‐ I ), apolipoprotein B ( A po B ), and adiponectin was significantly higher in AA broilers than in BJY broilers. In both breeds, BW , PAF , SFS , NEFA and TG were increased with increasing supplementation from 0 to 60 mg NA /kg, but then decreased slightly with 120 mg added NA /kg. With increasing supplementation, hepatic expression and plasma concentrations of adiponectin decreased from 0 to 60 mg added NA /kg and then increased with 120 mg added NA /kg. The expression of A po A ‐ I and A po B m RNA showed linear response to dietary supplementation with NA . These findings indicate that: (i) supplementation of NA influenced the lipid metabolism and related gene expression; (ii) when supplemented with 120 mg NA /kg, some pharmacologic actions on lipid metabolism appeared; and (iii) changes in BW and fat deposition appeared to be associated with hepatic expression of adiponectin.