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Associations between endotoxin‐induced metabolic changes and temperament in B rahman bulls ,
Author(s) -
Burdick Sanchez N. C.,
Carroll J. A.,
Randel R. D.,
Vann R. C.,
Welsh T. H.
Publication year - 2014
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/jpn.12074
Subject(s) - nefa , brahman , temperament , endocrinology , medicine , lipopolysaccharide , insulin , blood urea nitrogen , epinephrine , urea , zoology , babesia bigemina , biology , chemistry , biochemistry , breed , creatinine , psychology , personality , social psychology , babesiosis , virology
Summary The influence of temperament on the alteration of metabolic parameters in response to a lipopolysaccharide ( LPS ) challenge was investigated. Brahman bulls were selected based on temperament score. Bulls (10 months; 211 ± 5 kg BW ; n = 6, 8 and 7 for C alm, I ntermediate and T emperamental groups, respectively) were fitted with indwelling jugular catheters to evaluate peripheral blood concentrations of glucose, blood urea nitrogen ( BUN ), non‐esterified fatty acids ( NEFA ), insulin, epinephrine and cortisol before and after LPS administration (0.5 μg/kg BW LPS ). Feed intake was also recorded. Intermediate bulls consumed more feed than the T emperamental bulls during the challenge (p = 0.046). Pre‐ LPS glucose (p = 0.401) and BUN (p = 0.222) did not differ among the temperament groups. However, pre‐ LPS insulin (p = 0.023) was lower, whereas pre‐ LPS NEFA (p < 0.001), cortisol (p < 0.001) and epinephrine (p < 0.001) were greater in T emperamental than in C alm and I ntermediate bulls. Post‐ LPS glucose was increased in C alm and I ntermediate bulls but not in T emperamental bulls (p < 0.001). Insulin concentrations post‐ LPS were greater in C alm than in I ntermediate and T emperamental bulls (p < 0.001). Concentrations of NEFA post‐ LPS were greater in T emperamental than in C alm and I ntermediate bulls (p < 0.001). Serum BUN concentration increased post‐ LPS , with values being greater in C alm and I ntermediate than in T emperamental bulls (p = 0.012). Collectively, these data demonstrate that animal temperament is related to the metabolic responses of B rahman bulls following a provocative endotoxin challenge. Specifically, Temperamental bulls may preferentially utilize an alternate energy source (i.e. NEFA ) to a greater degree than do bulls of C alm and Intermediate temperaments. The use of circulating NEFA from lipolysis may reduce the negative metabolic consequences of an immune response by allowing for a prompt answer to increasing energy demands required during immunological challenge, compared with the time required for glycogenolysis and gluconeogenesis.