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Alternate‐day fasting diet improves fructose‐induced insulin resistance in mice
Author(s) -
Beigy M.,
Vakili S.,
Berijani S.,
Aminizade M.,
AhmadiDastgerdi M.,
Meshkani R.
Publication year - 2013
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/jpn.12022
Subject(s) - fructose , insulin resistance , medicine , endocrinology , insulin , calorie , blood sugar , sugar , zoology , biology , food science , diabetes mellitus
Summary Increased fructose consumption is linked to insulin resistance, weight gain, hyperlipidemia and hypertension. Although the advantages of several dietary restriction regimens have been demonstrated, the effects of alternate‐day fasting ( ADF ) on fructose‐induced insulin resistance have not yet been studied. This study is based on a new modification on ADF by combining the fructose‐rich solution (10% w/v) and regular mice diet. Mice were randomly allocated into four groups: ADF 50% (50% restriction in chow food intake but ad libitum fructose drink), ADF 100% (100% restriction for chow food but ad libitum fructose drink), control ( ad libitum chow food intake plus tap water) and daily food and fructose ( DFF ) (had free access to both chow and fructose solution). Biweekly fasting blood sugar ( FBS ), glucose tolerance test ( GTT ) and insulin tolerance test ( ITT ) were conducted. All groups gained weight during the study (p < 0.05). Body weights of DFF and control groups did not differ from that of ADF groups, but ADF 50% gained more (p < 0.01) weights than ADF 100% through the study. Total calorie intake (feed + fast days) of ADF 50% was higher than that of ADF 100% (p < 0.001) and control (p < 0.03). In addition, ADF groups consumed more energy than the control and DFF groups in feed ( ad libitum ) days (p < 0.05). At the end of the study, the mean FBS levels in the control and ADF 100% groups were similar and significantly lower in relation to that of DFF and ADF 50% groups (p < 0.01). Measurements of area under the curve in GTT and ITT revealed that the ADF 100% group was more insulin‐sensitive than the DFF and ADF 50% groups. In conclusion, these data suggest that the ADF 100% improves fructose‐induced insulin resistance in mice.