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Decreased melatonin secretion in patients with glaucoma: Quantitative association with glaucoma severity in the LIGHT study
Author(s) -
Yoshikawa Tadanobu,
Obayashi Kenji,
Miyata Kimie,
Saeki Keigo,
Ogata Nahoko
Publication year - 2020
Publication title -
journal of pineal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 131
eISSN - 1600-079X
pISSN - 0742-3098
DOI - 10.1111/jpi.12662
Subject(s) - glaucoma , melatonin , circadian rhythm , medicine , ophthalmology , creatinine , intraocular pressure , endocrinology
Abstract Glaucoma may be associated with circadian disruption due to its association with a loss of intrinsically photosensitive retinal ganglion cells. Clinical evidence demonstrating an association between glaucoma and circadian disruption is limited, and no large‐scale studies have been performed. The purpose of this cross‐sectional study was to determine whether the presence and severity of glaucoma is correlated with the urinary 6‐sulfatoxymelatonin levels as a circadian rhythm parameter. We measured the level of urinary 6‐sulfatoxymelatonin excretion (UME) in 118 glaucoma patients and 395 control participants without glaucoma. The UME in the glaucoma group was significantly lower than that of the control group without glaucoma (3.05 and 3.24 log ng/mg creatinine, respectively; P = .010). Next, we examined association of the severity of glaucoma and melatonin levels. In stratification analysis of the glaucoma groups, multivariable linear regression analyses adjusted for potential confounders indicated significantly lower UME by 0.30 log ng/mg creatinine in patients with functional severe glaucoma (visual field mean deviation ≤ −6 dB) compared with mild glaucoma (mean deviation > −6 dB; P = .040) and lower UME by 0.05 log ng/mg creatinine with each 10 μm thinning of the circumpapillary retinal nerve fiber layer thickness as the index of structural severity of glaucoma ( P = .011). In conclusion, significant association between glaucoma and lower urinary 6‐sulfatoxymelatonin was found. In addition, patients with functional and structural severe glaucoma were significantly associated with lower urinary 6‐sulfatoxymelatonin levels. Our results indicate the possibility of a circadian disruption in patients with glaucoma.