Open AccessAnalgesic effect of S (+)‐flurbiprofen plaster in a rat model of knee arthritis: analysis of gait and synovial fluid prostaglandin E 2 levels
Author(s) -
Fukumoto Ayaka,
Tajima Kyoko,
Hori Miyuki,
Toda Yoshihisa,
Kaku Shinsuke,
Matsumoto Hideo
Publication year - 2018
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/jphp.12914
Subject(s) - flurbiprofen , prostaglandin e2 , analgesic , synovial fluid , medicine , arthritis , knee arthritis , gait , knee joint , anesthesia , osteoarthritis , physical therapy , surgery , pathology , alternative medicine
Objectives We developed S (+)‐flurbiprofen plaster ( SFPP ), a novel NSAID patch containing S (+)‐flurbiprofen ( SFP ), a potent cyclooxygenase ( COX ) inhibitor. The purpose of this study was to assess efficacy of SFPP by analysing its effect on the gait disturbance and measuring the prostaglandin E 2 ( PGE 2 ) production in synovial fluid in a rat model of knee arthritis. Methods Knee inflammation was induced in rats by intra‐articular injection of a yeast suspension. Subsequently, an NSAID patch containing SFP , ketoprofen or loxoprofen was applied over the affected knee. Gait was assessed at 2, 4 and 6 h after application of the patch. The PGE 2 concentration in the synovial fluid was measured after the gait assessment. Key findings Application of SFPP (0.125, 0.25, 0.5 or 1 mg/sheet) was followed by a decrease in the visual gait score at all the doses examined. In the case of the other two NSAID patches, only the ketoprofen patch (1 or 2 mg/sheet) and loxoprofen patch (5 mg/sheet) produced a decrease in the visual gait score. All of the NSAID patches decreased the PGE 2 production in the synovial fluid. Conclusions These results suggest the potential usefulness of SFPP as an analgesic patch in patients with inflammatory joint pain.